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Teikyo Medical Journal


Journal ID : TMJ-21-12-2021-10918
Total View : 390

Title : Effect of Pumpkin Seed Oil on Histopathology of Pancreas and Some Biochemical Parameters of Stereptozotocin-Induced Diabetic Rabbits

Abstract :

We investigated the effects of pumpkin on pancreas tissues, histological features, and their impact on glycemic control serum insulin, and C-peptide. Our results showed a decrease in fasting blood glucose in pumpkin group when compared diabetic but this reduction was statistically significant. This experimental study was done in the Biochemistry department of the Faculty of Veterinary Medicine University. Diabetes mellitus was induced in 24 out of 32 adult male rabbits, using intraperitoneal injection of 35 mg/ kg BW stereptozotocin. The male rabbits, weighing 250±20 gr were randomly selected and divided into four following groups: control, diabetic (induced by 35 mg/kg mg/kg STZ) and treatment groups. The treatment group(G3&G4) were received pumpkin 100 & 200mg/kg orally once daily for four weeks. Following consumption of plants, blood glucose was measured every day and on the last day, Serum insulin and C-peptide levels were detected, and the pancreas were removed and stained with H&E. The results of this study indicate that the blood glucose increased while insulin and C-peptide level decreased in the diabetic groups compared with the healthy control group. In the treated group blood glucose significantly decreased while insulin and C-peptide level significantly increased when compared with diabetic group. The study showed that pumpkin extract by reducing blood glucose level and elevated serum levels of insulin and C-peptide has positive effects on morphology alterations in STZ-induced diabetic rabbits.

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Journal ID : TMJ-21-12-2021-10917
Total View : 407

Title : Clinical relevance of thickness and angulation of Lateral Lamella of Cribriform Plate-A Multidetector Computed Tomographic study

Abstract :

The morphometry and sexual dimorphism of lateral lamella of cribriform plate of the ethmoid bone provides assessement during various surgical procedures. This was prospective hospital based radiological study. Six hundred and forty four (644) Multidetector computed tomographic scans were collected from North Karnataka region and analyzed by using RadiAnt DICOM Viewer. The aim of this study was to determine the morphometry of the lateral lamella of cribriform plate of ethmoid bone. The thickness and angulation of lateral lamella of cribriform plate of olfactory fossa were calculated on both the sides in both genders. Statistical analysis was done by using Student unpaired‘t’ test. There was statistically significant difference in the angle of lateral lamella of cribriform plate when compared between right side (mean=106.25˚) and left side (mean=109.38˚) in males. There was no such difference among females. Statistically significant difference was observed in the angle of lateral lamella of cribriform plate in male patients (mean=106.25˚) when compared to female patients (mean=109.61˚). The thickness of lateral lamella of cribriform plate was not significant when compared between two sides in males and females. Hence, these variations in the morphometry of the lateral lamella of cribriform plate of ethmoid bone will be of importance for the surgeons in Functional endoscopic sinus surgeries and anterior skull base surgeries.

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Journal ID : TMJ-21-12-2021-10916
Total View : 420

Title : Study of laboratory and clinical parameters in children with connective tissue dysplasia in Yakutia

Abstract :

Visceral disorders of various organs and systems in children with connective tissue dysplasia (CTD) living in extreme climatogeographic conditions according to laboratory tests have been studied. The children (35 schoolchildren) aged 10 to 17 years old were divided into mild, moderate and pronounced CTD degrees. Selection of children was performed by CTD phenotypic signs with score assessment and definition of CTD severity. The results of laboratory studies revealed more than 90% cardiovascular system disorders in children with CTD, about 85% of digestive system disorders and 70% of visual disorders, 50% of urinary disorders were detected in half of the children, mineral metabolism was impaired in 44% of the children. The connective tissue dysplasia in 70% of the children causes changes of 2 or more systems and organs, and in half (55%) causes 3 or more systems and organs disorders. When examining children with EchoCG, almost the majority of Cardiovascular Development Abnormalities (CDA) were detected. In more than half of children, 65.8%, i.e. 25 children were diagnosed with mitral valve prolapse (MVP). Mitral valve regurgitation was found in 28 children (73.8%), MVP of the 1st degree was noted in half of children with CTD, and the second degree was noted in 16% of the children and adolescents. In ten children (26%), abnormally located chords (ALC) were diagnosed, 13 children (34%) showed additional trabecules. The compaction of the calices-pelvis system walls occupies a special place in children with CTD.

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Journal ID : TMJ-20-12-2021-10913
Total View : 433

Title : IN THE TREATMENT OF CHRONIC PLANTAR FASCIITIS, A COMPARITIVE STUDY BETWEEN SHOCKWAVE THERAPIES AND LOCAL CORTICOSTEROID INJECTION

Abstract :

One of the most prevalent ailments for which people seek treatment at a foot and ankle surgery facility is heel discomfort. Plantar fasciitis (PF) is almost one of the most common causes of adult heel pain, it account for 11 to 15% of all foot illnesses requiring medical care. The major presenting symptom is pain and soreness at the heel where the plantar fascia attached while starting weight bearing after lengthy periods of rest. Rest, nonsteroidal anti-inflammatory medicines (NSAIDs), stretching of the plantar fascia, physical therapy, foot cushioning, and orthotic devices, which may be utilized to meet the patient's demands, are some of the current conservative therapies for PF (planter fasciitis). In intractable instances of plantar fasciitis, where conservative therapy have failed to provide relief, steroid injections into the plantar fascia are often employed. Other treatment options for PF, including as extracorporeal shockwave therapy (ESWT) are advised if patients do not react to conservative therapies. This study included 50 patients with chronic PF who had failed to react to conservative treatments such as physical therapy, NSAIDs, stretching exercises, and heel cushions for at least 6 months, and who did not have flatfeet or gastrocnemius contracture met the inclusion criteria. Patients were randomly divided into 2 groups:25 patients will get radial Extracorporeal Shockwave Therapy (ESWT) once a week for six weeks (Group I).25 patients will get a single local corticosteroid injection at the plantar fascia's origin (40 mg/2 ml of methylprednisolone together with 1 ml of local anesthesia, once) (Group II). Assessment of heel pain was done at the start of the trial and before each session using VAS score which was the primary outcome measure at 1, 3 and 6 months. A total of 50 individuals with persistent planter fasciitis (PF) were included in this investigation. Their ages varied from 31 to 42 years old. Females made up 70% of the group, while males made up 30%. Group I: 25 patients with PF who got extracorporeal shockwave treatment for 6 weeks at a time (once a week). There were 17 ladies (68%) and 8 males (32%), with ages ranging from 28 to 44(mean SD 18.2). Group II: consisted of 25 individuals with PF who were given a local corticosteroid injection. There were 18 females (86.7 percent) and 7 men (13.3 percent) with ages ranging from 25 to 45 years (mean SD 21.9). Group I included 20 patients (80%) and group II had 22 patients (88%) had pain in one foot, whereas 5 (20%) patients, 3 (12%) patients had pain in both feet, with no statistically significant difference. There was no significant difference between the groups in terms of the VAS score at the start of the trial (p=0.26), mean VAS score were 6.4 & 6.2 in group I& II respectively. At 1 month mean VAS score were 1.6 & 1.2 in group I & II respectively. At 3 months mean VAS score was 2.2 & 1.7 then 5.1 & 2.3 at 6 month for group I &II respectively. ESWT and local corticosteroid injection therapies are safe and effective but Local Corticosteroid injection is more effective than ESWT in the treatment of chronic plantar fasciitis.

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Journal ID : TMJ-20-12-2021-10912
Total View : 466

Title : Lung and prostate epithelial tissues defects: oncogenic opportunities of human papillomavirus

Abstract :

The oncogenic role of human Papillomavirus (HPV) types in human tissues is a renewed subject since the discovery of probable HPV tumorigenesis mechanisms in cervical tissues and other tumor types. The cancerous tissues were observed to be high infected with HPV in comparison to healthy ones. But the HPV carcinogenesis mission at prostate, lung and other epithelial tissues are still controversial. Although this role is very possible, epidemiological studies did not confirm significant correlations between infection ratios in cancerous and healthy tissues. In this insight, we revised the potential HPV histological strategy for infecting lung and prostate epithelial tissues. Our suggestions are based on the previous HPV infection mechanisms regarding cervical and other reproductive system tumors and link this to histological manifestations before tumors initiation. Other recommendations to investigate the HPV oncogenic role in lung and prostate were presented.

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