The increase in cancer incidence needs to constantly improve treatment with the least side effects of medication. This descriptive study was conducted to evaluate physical side effects in cancer patients receiving chemotherapy. A study was conducted on 25 cancer patients receiving chemotherapy inside and outside Kirkuk governorate in northern Iraq, where data were collected using self-preparation of a questionnaire designed for each participant. The results showed that patients receiving chemotherapy had a variety of side effects, especially fatigue (84%) and anxiety (76%) in the most, while stomatitis was the least (48%). We concluded in this study that it is requisite to conduct a routine examination of the side effects of chemotherapy and to provide moral support to cancer patients.