Abstract :
Acute respiratory distress syndrome (ARDS) had been associated with high mortality and ICU admission. Several studies had found the association between vitamin D level and risk of ARDS. The objective of this systematic review was to determine the association between vitamin D deficiency and ARDS. This systematic review used online databases (Google Scholar, PubMed, Science Direct, and CENTRAL) in obtaining eligible journals. All published observational studies that determine the association between levels of vitamin D and the incidence or prevalence of ARDS were included. The search yielded 5 journals. Severe vitamin D deficiency was associated with a higher APACHE II score, SOFA score, and DCI score, lower PaO2/FiO2, higher duration of mechanical ventilation, and longer ICU hospitalization. Vitamin D level was significantly lower in ARDS patients with vitamin D deficiency, especially in severe deficiency group compared to the control group (p < 0.005). Severe vitamin D deficiency is associated with worse clinical outcomes and severe ARDS.
