Title : TP53 promoter methylation in HPV associated breast cancer among women

The methylation of the promoter TP 53 was examined in fresh biopsies of sporadic breast cancer in Moroccan women with HPV infection. This study was performed on 50 patients. The samples treated with bisulfite followed by MSP with methylation-specific primers. HPV research performed by a nested PCR. Studies indicated a high frequency of methylation in HPV-associated cases (72%) and not significant p53 promoter methylation profile (78%). Methylation of the p53 gene promoter in combination with direct HPV infection affects the likelihood of breast cancer.