04 Dec 2023
30 Nov 2023
Thyroidectomy is common and is performed for malignancy, goiters with pressure symptoms, and certain types of Grave's disease. Weight and body mass index (BMI) following thyroidectomy were discussed controversially. This meta-analysis aimed to assess weight and MBI following thyroidectomy. A systematic literature search was conducted in PubMed, Medline, and Google Scholar with interest in articles that assessed body weight and body mass index following total or subtotal thyroidectomy. The search engine was limited to the period from inception up to October 2022. The keywords total thyroidectomy, subtotal thyroidectomy; Graves' disease, multinodular goiter, differentiated thyroid carcinoma, and toxic nodules were used. Out of the 634 articles retrieved, 89 full texts were screened, and only six studies (five retrospective and one prospective cohort) fulfilled the inclusion and exclusion criteria. No differences were evident regarding weight and BMI before and after thyroidectomy (odd ratio, -0.63, 95% CI, -1.50-0.24, P-value for overall effect, 0.15 and -0.12, 95% CI, -0.41-0.16, P-value for overall effect, 0.40 respectively. No heterogeneity was observed, I2 for heterogeneity, 0.0%. No association between thyroidectomy (when performed for differentiated thyroid carcinoma and hyperthyroidism), weight, and body mass index. Further studies assessing thyroid stimulating hormone levels, radioactive iodine therapy, and thyroxine dose are needed.