The posterior lumbar decompression and stabilization procedures often were related to severe postoperative pain due to intraoperative spinal muscles, ligaments, and bones tissue trauma and retraction. Severe perioperative pain can trigger unexpected sympathetic responses, increase perioperative morbidity and mortality, prevent early mobilization and rehabilitation, and delay the recovery process. Ultrasound-guided Thoracolumbar Interfascial Plane Block (TLIP) is an interfascial plane block that can provide adequate analgesia during spine surgery. We report 3 cases of posterior decompression and stabilization procedures who had multi-segmental lumbar TLIP block for perioperative analgesia. Despite good postoperative analgesia, we found that TLIP block could effectively provide intraoperative haemodynamic stability with low intraoperative opioid consumption without any complications found.