Submission Deadline
02 Dec 2022 (Vol 45 , Iss 10 )

Upcoming Publication
30 Nov 2022 (Vol 45 , Iss 09 )

Journal ID : TMJ-30-11-2021-10833
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Title : The role of Natural Killer Cells in the Pathogenesis of COVID-19

Abstract :

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is now causing a pandemic with a rapid spread and become a global public health problem. Coronavirus illness-2019 is a potentially lethal disease, especially for patients with comorbidities. Natural killer (NK) cells are important in controlling the immunological response in COVID-19 patients, but their effector capabilities are disturbed in those with comorbidities. Preliminary research in COVID-19 patients with severe illness reveals a drop in NK cells quantity and activity, leading to a decrease in the clearance of infected and activated cells and an unregulated rise in tissue-damaging inflammatory markers. Knowing the mechanism and role of NK cells in COVID-19 becomes necessary for better understanding and treatment of COVID-19.

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