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05 Jul 2022 (Vol 45 , Iss 05 )

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31 Jul 2022 (Vol 45 , Iss 05 )

Journal ID : TMJ-08-04-2022-11238
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Title : THE RELATIONSHIP BETWEEN PROCALCITONIN LEVEL IN SEVERE PREECLAMPSIA AND NORMOTENSIVE PREGNANCY

Abstract :

Preeclampsia is characterized by hypertension and proteinuria after 20 weeks of gestation. Several studies have found that pro-inflammatory cytokine levels were higher in preeclampsia patients than women with normotensive pregnancy, one of which was procalcitonin. However, at present, whether procalcitonin (PCT) level increases in patients with severe preeclampsia is still debatable. To determine the relationship between procalcitonin level in severe preeclampsia and women with normotensive pregnancy. Sampling collection in this study was obtained using the executive sampling method. There were 50 study samples, consisting of 25 pregnant patients with severe preeclampsia and 25 normotensive pregnant patients who underwent delivery at Prof. Dr. R. D. Kandou Manado General Hospital and Related Hospital in Manado City. Measurement of Procalcitonin level in all sample was performed and then data analyzed using SPSS software version 20.0. Procalcitonin levels in pregnant women with severe preeclampsia was 0.100 (0.020.00–0.900) ng/mL. Procalcitonin level in normotensive pregnant women was 0.040 (0.0150–0.045) ng/mL. There was a significant relationship (p <0.001) between PCT level and severe preeclampsia events. Severe preeclampsia patients had a higher PCT level than normotensive pregnant women. Patients with PCT level ≥0.095 ng/mL had a relative risk of experiencing severe preeclampsia of 4.125 (Confidence interval [CI] 95%, 2,257-7,540); and had a specificity and sensitivity of 100% and 68%, respectively. There was a significant relationship between PCT levels and the incidence of severe preeclampsia. Severe preeclampsia patients had a higher PCT level than normotensive pregnant women.

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