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Journal ID : TMJ-14-06-2022-11317
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Title : The relationship between pregnancy and serum vitamin B9 and B12.

Abstract :

Folate (vitamin B9) is a necessary ingredient for DNA replication. Also used as a substrate in a variety of enzymatic processes involved in amino acid synthesis and vitamin metabolism. Vitamin B12, commonly known as cobalamin, is a water-soluble vitamin. It comes in cyano-, methyl-, deoxyadenosyl-, and hydroxy-cobalamin forms. From December to June 2019, 50 pregnant women were registered in Al-Karkh Materuity Hospital. After obtaining informed consent, fasting blood (n=25) was taken by a single puncture from patients (either demonstrated vitamin B9 or B12 deficiency) and healthy volunteers (n=25). The weight of the baby at birth, the type of delivery, and the length of the pregnancy were all documented. After gaining oral agreement from the participants, fasting blood (2ml) was taken from the vein in plain vacutainers. Commercially available tests were used to determine the levels of vitamin B9 (folate) and vitamin B12 in the blood (Sigma, USA). GraphPad Instat was used to calculate the statistical significance of the unpaired t-test (3.0, Trial Version). Women with low vitamin B9 levels had a significantly lower fetal weight (p0.0001) than healthy controls. Similarly, as compared to healthy controls, B12 deficient women had lower infant birth weights. Vitamin B9 levels in healthy controls were 174.3821385.17 pmol/l, while they were 119.878525.81 pmol/l in B9 deficient subjects. The vitamin B12 concentration in the B12 deficient group was substantially lower (211.64931.71pg/ml) than in the healthy control group (401.47258.94 pg/ml). We may conclude from this research that vitamins B9 and B12 are critical for the growth and development of the fetus. The supplementing should begin before the pregnancy is planned. Folate (Vitamin B9) and vitamin B12 are linked to pregnancy difficulties in a negative way.

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