The study showed for the first time the possibility of using the method of X-ray fluorescence analysis as a method for monitoring the balance of micronutrients in the bodies of both males and females with different body mass indexes. Young people aged ≥ 18 years old living in the Grodno region showed zinc, calcium, iron, potassium, and copper imbalances, depending on their BMI. As a consequence, nutrition may be corrected early. The results show that the imbalance in the elemental status in patients with overweight, both males and females in the age group ≥ 18 years (Young people), is clearly correlated with the level of hormonal background (T3, T4, TSH, cortisol), metabolites, substrates, and enzymes of blood plasma (glucose, CH, LDL, TG, alanine aminotransfer. As a result of an imbalance in mineral metabolism, dysmicroelementosis develops as well as metabolic processes are disrupted. Vitamin D deficiency was found in 50% of males and females with a BMI = 25–29.9 (males and females). A high TSH level is linked to an increased risk of weight gain and obesity. Among adults with a BMI = 25–29.9, a high TSH level raises the risk of an increase in BMI and, when combined with other risk factors, is an additional autonomous sign of the danger of obesity (increased TSH concentration correlates with increased glucose levels). The characteristics of the lipid spectrum and the level of TSH have been found to have a moderate direct association.