This study aimed to investigate the risk and trend of children leukemia in Mosul, Iraq, over the year 2020. Between January and December 2020, research was undertaken on the hospital registry. The study included all children with leukemia aged one to fourteen years at the Nuclear Medicine Hospital in city of Mosul, Iraq. All confirmed childhood leukemia data were obtained and analyzed. The individual incidence rates were computed. From January to December 2020, there were 66 instances of pediatric leukemia. During this time period, the total age-standardized incidence rate (ASIR) was 5.45/100000. During this 5-year period, no temporal rise in children leukemia incidence rates was detected. Acute lymphoblastic leukemia (ALL) was the most prevalent kind of leukemia in this research, followed by acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Males had a higher prevalence of all leukemia subtypes. The greatest rates of ALL and CML were found in children aged 2 to 5 years. AML was more frequent between the ages of 6 and 14 years. In Mosul, leukemia was the most frequent pediatric cancer. Although there was no temporal rise in pediatric leukemia incidence rates during2020, the incidence of leukemia in children in Mosul was greater when compared to other nations. Epidemiological research is required to understand the cause of pediatric leukemia in Mosul.