The goal of this study was to see how effective and safe topical cacipotriol/betamethasone dipropionate ointment is "in treating nail psoriasis in a number of Iraqi patients". Treatment of psoriatic nail still a challenge, there are a limitation in clinical data and outcomes of the disease. Systemic therapies are only utilized in moderate to severe cases of psoriatic arthropathy or widespread cutaneous involvement in addition to several side effects that limit their use. A thirty two patients instructed to apply Cacipotriol/Betamethasone dipropionate ointment(Daivobet®) once daily to the affected nails including nail folds for six months duration. NAPSI scores were used to assess the outcome measures at baseline, 4th, 8th, 12th, 16th, 20th and 24th weeks. Final evaluation was analyzed by percent of reduction from baseline of NAPSI score. The response to the treatment started to notice after 12week of treatment by the reduction of mean NAPSI to 6.05 ± 4.82 (-4.81) by percent of reduction 44.29% while mean NAPSI decreased from10.86±5.82 at baseline to 2.10 ± 3.21 (-8.67) after 24 weeks of treatment. Overall improvement was 79.18% reduction in NAPSI which is very satisfying. The two-compound ointment contains calcipotriol and betamethasone dipropionate was found to improve nail psoriasis when administered once daily for 24 weeks.