Post-tonsillectomy pain is an undesirable complication that can affect a patient’s emotion and daily activity. There have been many studies on different surgical techniques and medications to find the best treatment to alleviate pain in post-tonsillectomy patients. This study aims to compare the effectiveness of oral gargle and throat spray as different modes of delivery of benzydamine hydrochloride in post-tonsillectomy pain control. We focused on local analgesia using different methods of delivery. A total of 92 patients aged between 13 and 40 who underwent tonsillectomy with or without adenotonsillectomy, were included. They were randomly divided into two groups: gargle group and spray group, with 46 patients in each group. Pain score using Visual Analogue Score (VAS) was assessed for both groups at least six hours post operation as the baseline pain score, followed by assessments at days 1, 4 and 7. There was a significant difference in the VAS pain scores between the two modes of benzydamine hydrochloride delivery. The gargle group reported higher pain scores compared to the throat spray group (p < 0.001). In conclusion, using throat spray as a method to deliver local analgesia provides greater benefit in pain control for post-tonsillectomy patients, to the use of oral gargle. So, we can consider prescribing throat spray for treating the post-tonsillectomy pain perhaps it can prevent further complications such as dehydration, infection and bleeding.