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21 May 2022 (Vol 45 , Iss 04 )

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31 May 2022 (Vol 45 , Iss 03 )

Journal ID : TMJ-10-12-2021-10869
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Title : The Effect of Moringa Leaf (Moringa Oleifera) Extract Against Renal Histopathology of Diabetes Mellitus Wistar Rats

Abstract :

Diabetes Mellitus is a condition in which blood glucose level increases in a person's body that can lead to chronic disorders. The effects of diabetes mellitus on Kidney problems such as diabetic nephropathy can occur. Moringa leaf (Moringa Oleifera) is rich in antioxidants such as flavonoid, vitamin C, vitamin E, and vitamin A, and contain selenium which will help lower blood sugar level. This research was conducted to determine the effect of giving Moringa leaf extract (Moringa Oleifera) against the kidneys of Wistar rats with diabetes mellitus. This study was an experimental research, the methods applied were pre and post randomized controlled group design. It included changes in the pathological histological structure of the kidney such as: tubular cell degeneration, tubular cell inflammation, and irreversible tubular cell changes such as lumen atrophy or dilation, necrosis, interstitial hemorrhage, tubular cell fibrosis. This study was divided into 4 groups: one as the control group, and three as the treatment group induced with alloxan and given ethanol extract of Moringa leaf at doses of 250, 500, and 750 mg/KgBW. The results indicated that the ethanol extract of Moringa leaf at various doses demonstrated significant improvement (P value ≤ 0.05).

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