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02 Dec 2022 (Vol 45 , Iss 10 )

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30 Nov 2022 (Vol 45 , Iss 09 )

Journal ID : TMJ-29-12-2021-10934
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Title : The correlation of clinico-demographic variance with the endoscopic and histopathologic yields for patients with dyspepsia; a prospective observational study

Abstract :

General practitioners and gastroenterologists often see patients with dyspepsia. It is the gold standard for diagnosis to perform an upper GIT endoscopy with biopsy, however it is not available in all hospitals, plus many patients don't accept its invasive nature. Studying endoscopic and histopathologic changes in dyspepsia patients was the purpose of this study. The study included 132 patients with dyspeptic symptoms attending the gastroenterology clinic for an endoscopy. An in-depth history was taken in all cases included, clinical examination and laboratory investigation. Abdominal ultrasonography, H.pylori stool antigen testing, and upper GIT endoscopy and biopsy were performed on all the cases. Their ages ranged from 20 to 58, with 56 males and 76 females. As compared with histological findings, the stool antigen test had 63.2% sensitivity, 71.4% specificity, a PPV of 75% and a NPV of 58.8% in detecting H pylori. Gastritis was the most detected pathological finding in the included cases, and endoscopic findings were normal in most of them. Most of the cases were positive for H. pylori stool antigens indicating high prevalence among cases with upper GIT symptoms. Most of them had benign pathology on histopathological analysis. Stool antigen test for H. Pylori revealed high sensitivity in comparison with histopathological findings in diagnosis of cases with upper GIT symptoms.

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