Abstract :
Pregnant women are considered to be more susceptible to severe COVID-19 respiratory infections due to physiological and anatomical changes. In addition to its impact on cardiac and pulmonary physiology, pregnancy is also characterized by several changes in the immunological profile or biomarkers. Changes in levels of biomarkers such as C-reactive protein (CRP), lactate dehydrogenase (LDH), ferritin, and D-dimer have been considered as tools to monitor the severity of COVID-19 infection. This study was conducted to explore the specific role of CRP and D-dimer in COVID-19 pregnant patients. This research is an observational analytical study. The number of research samples was 40 samples consisting of 20 pregnant women with mild COVID-19 symptoms and 20 pregnant women with moderate-severe COVID-19 symptoms who were treated at the obstetric emergency care unit (IRDO) Prof. RSUP. Dr. RD Kandou Manado in August 2021. The data were then analyzed using SPSS 25 software for Windows. In the group of pregnant women with mild COVID-19 symptoms, the mean±SD value of CRP levels was 25.69±3.155 and D-Dimer levels were 2.6956±0.42413; while in the group of pregnant women with moderate to severe symptoms of COVID-19, the mean ± SD value of CRP levels was 42.57 ± 2.615 and D-Dimer levels were 12.3481 ± 1.86270. So from this study it was found that maternal CRP and D-Dimer levels were on average lower in pregnant women with mild COVID-19 symptoms than moderate-severe symptoms. There is a significant relationship between maternal serum CRP levels (p=0.001) and maternal serum D-Dimer levels (p=0.000) against Covid-19 pregnant women with mild and moderate-severe symptoms.
