The behavioral and psychological symptoms of Alzheimer's disease intervene in the life of the patient's caregivers. This study aims to identify the burden and psychological impact on the caregivers of Alzheimer's patients in Saudi Arabia. It is a cross-sectional study of a sample consisting of ninety-six participants living in Saudi Arabia assessed demographics, stress level, and quality of life of the caregivers. The study showed that 82.3% of the caregivers are sons and spouses of Alzheimer's patients, and 74% were female. It showed that 47.9% of the caregivers revealed that they feel worried all the time, and 56.3% of the caregivers reported moderate to severe levels of sadness. Moreover, there is a social dysfunction that 58.3% of the caregiver's relationships with others have been affected since they started taking care of Alzheimer's patients. They confirmed that taking care of Alzheimer's patients has a negative impact on their daily time. Economically, 63.5% of the caregivers state that their financial status allows them to keep taking care of the patient. The study found that half of the caregivers felt worried, and more than half felt sad while looking after the patient. In addition, we found that although most caregivers are female, males had significantly more impact regarding their ability to do a daily activity, which we attributed to the fact that the male full-time employment rate was higher. Further researches are recommended to determine the exact prevalence of depression and anxiety.