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25 Apr 2024 (Vol 47 , Iss 04 )

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30 Apr 2024 (Vol 47 , Iss 04 )

Journal ID : TMJ-14-02-2022-11127
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Title : The association of hypogonadism with type 2 diabetes mellitus and obesity

Abstract :

Prevalence of hypogonadism was higher among patients with comorbid conditions, such as type 2 diabetes mellitus and obesity. To assess the relationship of hypogonadism with diabetes mellitus and obesity based on positive symptoms and low testosterone level in Iraqi men and to identify the factors that associated with low serum testosterone level. A case control study included 200 patients and divided into two groups; Case group included 100 patients who were a known case of type 2 diabetes (type 2 diabetes) and control group included 100 persons who attended for reasons other than diabetes. All the study patients were investigated for total testosterone, FSH, and LH hormones. SHBG and glycated hemoglobin was done for case group only. Ten milliliters of venous blood sample were taken between 8 – 10 AM. Total testosterone level was low in 56% of case group compared to 19% in control group, and this difference was significant. Means of LH, and FSH were significantly lower in diabetic patients than that in controls. Prevalence of low free testosterone level was significantly increasing with II increasing in BMI level and in-patient who had high waist circumference. we notes that the prevalence of low free testosterone level was significantly increasing with increasing in duration of diabetes and in patient who had high HbA1c level. There were statistical significant associations between low mood, erectile dysfunction, and decreased libido with low free testosterone level. Statistically significant negative correlations were detected between calculated free testosterone and all of BMI, waist circumference, duration of diabetes, and HbA1c. Significant number of men with type 2 diabetes have low total and calculated free testosterone and inappropriate low or lower normal LH and FSH. There are inverse relationships between BMI and waist circumference with serum testosterone levels in men with type 2 diabetes.

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