Diabetes mellitus is one of the most prevalent non-chronic diseases worldwide. Type I diabetic patients are the leading cause of death, of which 30%-40% suffering, diabetic nephropathy affects 40% of type 2 diabetics, resulting in end-stage renal failure. Various types of chronic renal parenchymal diseases are linked to increased renal resistance. Renal resistive index (RI) is a duplex ultrasound-derived metric that displays the arterial waveform which can show dynamic or systemic improvements in intra-renal arteries and renal dysfunction and is strongly related to renal arteriolosclerosis and adverse cardiovascular events, in an adult, the typical RI range is 0.47 to 0.70, with a difference of 5 to 8% between two kidneys. The improved utility of RI has demonstrated detrimental development of renal diseasein T2DM patients, but its therapeutic relevance has been debated. The study’s main purpose is to perform the systematic analysis to determine the exact association between intra-renal artery resistive index and biochemical parameters in type 2 diabetic patients. The data for systematic review was taken from prospective, placebo-controlled study, double-blind, and double-blind, multicenter, randomized controlled trial prerecorded, Cochrane Systematic Review Database, EMBASE, Cochrane Collaboration Randomized Trials Database (Primary), MEDLINE, Cochrane Central Clinical Trials Registry, PubMed, Bio Med-Central, Scopus as well as Google Scholar, to evaluate the objective during the period of 1999s to 2021. This research results reveals that biomarkers and renal RI are strongly associated with the risk factor for people with Type- II diabetes and the development of renal failure.