Abstract :
We studied the parameters of lipid and carbohydrate metabolism, the level of thyroid hormones in men in Iraq with disorders of the hormonal functions of the pancreas and thyroid glands, obtained in the clinical laboratory of the Diwaniyah Teaching Hospital Laboratory (Diwaniya, Iraq) in 118 male patients with established diagnoses of type 2 diabetes mellitus (T2DM), hypothyroidism, T2DM + hypothyroidism, hyperthyroidism, as well as in males without hormonal pathology (control). The age of the patients was 38 - 42 years old. When studying lipid metabolism disorders in males with shifts in thyroid status, T2DM and a combination of T2DM + hypothyroidism, it was found that in the group with hyperthyroidism, lipid metabolism indicators are close to those in the control group, however, those correlations between changes in individual indicators that are characteristic of the control group are not revealed. In groups of hypothyroidism or T2DM, most of the correlations between indicators are also lost, which, obviously, leads to lipid imbalance in these groups. When hypothyroidism is combined with T2DM, deviations of lipid metabolism indicators from those in the control group are practically absent, however, the spectrum of metabolic relationships changes significantly and new mechanisms for maintaining homeostasis are formed, as evidenced by the emergence of close correlations between changes in individual indicators of not only lipid metabolism, but also thyroid hormones. The study of laboratory parameters using correlation and discriminatory analysis showed that with combined pathology, metabolic flows in the cell are dysregulated, lipid status changes, new correlations are formed between thyroid hormones and lipid metabolism parameters. It was found that the main contribution to the formation of a new state of metabolic balance is made by changes in the level of T4, LDL and cholesterol, which, together with the changes in the content of HDL and triglycerides, caused by them, affect other indicators of thyroid and lipid status. Obviously, when assessing metabolic disorders caused by hormonal imbalance in T2DM + hypothyroidism, it is necessary to assess both the content of individual components of lipid metabolism and thyroid status, and the presence of a relationship between them. Correlation and discriminatory analysis of the data makes it possible to identify the leading factors that make the most significant contribution to the formation of a new state of metabolic balance with a combination of thyroid dysfunction and T2DM.
