Rhinovirus ubiquitous seasonal pathogen and has been linked to emergence, the first is for wheezing in children and exacerbation of asthma in patients of all ages, Bacterial species have a role in upper respiratory infections and exacerbation of asthma in adults. The research aims to clarify the relationship between Rhinovirus and bacteria that cause infections, The upper respiratory tract and its relationship to asthma. In 200 patients with acute upper respiratory tract infection and asthma Swabs were obtained from the throat to detected pathogenic and commensal bacteria in the throat, and species and sera from these individual for identification RV antibodies IgM, IgG, determination of RV Antigen. Culture results showed that 37.5% were commensal bacteria and The percentage of pathogenic bacteria was rate of 70%, BacterialSpecies isolated (Staph. aureus, Strep. pyogens, H.influenzae ,K.pneumonia ,Strep. Pneumonia P.aeroginosa,E.coli ,S. marcescens), Serological testing using ELISA showed that Rhinovirus infection exacerbation asthma and URTI. type of antigen and Antibody showed a change depending on the sex group.