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20 Jun 2024 (Vol 47 , Iss 06 )

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30 Jun 2024 (Vol 47 , Iss 06 )

Journal ID : TMJ-29-01-2022-11058
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Title : Residual effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin ( TCDD ) toxicity in liver and pathological changes of the intestine in albino male rats

Abstract :

This study provides the residual effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the liver and pathological changes of intestine albino in male rats. The present study aimed to detect the influence of TCDD in the male rats; the present study was included (118 albino male rats) divided into three groups, their age ranged from 8-9 weeks, the LD50 of TCDD (70.7 µg /kg) and the period of this study 90 days. The results showed the standard of TCDD (33.90 ppb) while the remaining amount of TCDD (3.87 ppb) in the liver tissue in the 2nd group, which was less than its amount (6.42 ppb) in the 3rd group. The pathological examination revealed in 2nd & 3rd group in intestine showed sloughing & desquamation with dark basophilic crypt ( mucosa ) with increased in number & size of goblet cells, irregular & shorten villi, ulcerative mucosa with necrotic villi, congested & clotted blood vessels in mucosal layer with severe mononuclear cells infiltration.

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