Abstract :
After improving the survival of patients with β-thalassemia, it lets several clinical morbidities to manifest, like nephrological complications. Patients may have abnormalities in glomerular filtration rate and proximal renal tubules dysfunctions. The aim of this study was to explore prevalence and risk factors of renal tubular dysfunction in Egyptians adult’s patients with TDBT. This case series study was carried out on 86 adult patients with transfusion dependent beta-thalassemia (44 females and 42 males), their age ranged from 18 to 41 years; they were selected from Thalassemia Unit, Faculty of Medicine, Menoufia University from the period of December 2019 till June 2020. Results showed that 18 patients (20.9%) have renal tubular dysfunction out of total 86 patients according to β-2 microglobulin levels in urine. Significant correlation between Phosphorus in urine, proteinuria & duration of disease with renal tubular dysfunction that may help in prediction of tubular dysfunction in adults patients with transfusion dependent beta-thalassemia, Age and family history are independent risk factors for RTD in TDBT. This study shows that tubular dysfunctions is a major problem present in about (20.9%) of adults with TDBT. Phosphorus in urine, proteinuria & duration of disease may help in prediction of tubular dysfunction in adults with TDBT.
