The present study aimed at the evaluation of the association between H.pylori and dental caries by a systematic review and meta-analysis study. We searched databases, including PubMed and Google Scholar using the following keywords in English: H.pylori, dental caries. Among 113 articles reviewed that included 3595 patients samples. Results showed that association between H. pylori and dental caries was significant with OR (odds ratio) = 1.13. These results reveal that H. pylori could be one of the main causes of periodontal diseases. We recommend a novel approach should be employed for the complete management of H. pylori infections.