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Journal ID : TMJ-20-10-2022-11425
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Title : Relationship Between COX-2 Expression with ER, PR, HER-2, and KI-67 Expression in Breasr Cancer Patients at Dr Saiful Anwar Malang Hospital

Abstract :

Breast cancer is a malignancy of the breast which is one of the leading causes of death in women. COX-2 plays a role in increasing cell proliferation, delaying apoptosis, increasing angiogenesis, and increasing invasiveness of surrounding cells. Non-steroidal anti-inflammatory drug (NSAID) or anti-COX-2 therapy has the potential to reduce COX-2 overexpression and decrease breast cancer progression. COX-2 expression is thought to be related to hormone receptor expression of ER, PR HER-2, and Ki-67. The purpose of this study was to determine the relationship between COX-2 expression and ER, PR, HER-2, and KI-67 expression in breast cancer patients at DR Saiful Anwar Hospital, Malang so that it can be used as a basis for NSAID therapy. This study using cross-sectional study and carried out with a time span of July-November 2021 at the Anatomical Pathology Installation of Saiful Anwar Hospital, Malang. Sampling using consecutive sampling method with a total sample of 30 samples of breast cancer tissue. COX-2 expression with ER, PR, HER-2, and KI-67 was analyzed using Kendall's tau B with a significance level of p<0.05. There is a correlation between COX-2 expression with PR (r=-0.382; p=0.037) and Ki-67 (r=0.532;p=0.004). There was no correlation between COX-2 expression with ER and HER-2 receptors (p>0.05). COX-2 expression was negatively correlated with PR and positively correlated with Ki-67.

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