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Journal ID : TMJ-02-03-2022-11163
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Title : Quality of Life in Oral Lichen Planus: a Meta-Analysis

Abstract :

To evaluate the most frequently used severity measuring instrument and the most affected quality of life (QoL) domain on OLP patients. Systematic review and meta analysis. Three reviewers conducted electronic searching on three databases (PubMed, Wiley Online Library, Clinical Key) according to PRISMA. Cross-sectional, case-control, and cohort designs were included. JBI and NOS risk of bias tools were used to assess these studies. The outcome was recorded based on the QoL instrument. No time limit for studies. Meta-analysis using fixed-effect modelling was taken. The study's mean difference (MD) and odds ratio (OR) were pooled. Thirteen publications were included out of 1279 found. The most frequently used objective severity measuring instruments are the Thongprasom scale and ODSS; the latter was the most effective. The most frequently used instrument and most effective measure of pain were NRS. Two studies were included for meta-analysis. The most frequently used quality of life measuring instrument is OHIP-14, whereas affected domains are physical pain (MD=1.416; 95%CI 0.632-2.200; p=<0.001), psychological discomfort (MD=0.958; 95%CI 0.254-1.662; p=0.008), physical disability (MD=0.9; 95%CI 0.295-1.504; p=0.004), social disability (MD=0.681; 95%CI 0.160-1.203; p=0.01), and handicap (MD=0.576; 95%CI 0.063-1.09; p=0.028). Using appropriate instruments could measure OLP severity degree subjectively and objectively. OHIP-14 could measure the five most affected domains associated with this lesion. OSF registration number were obtained: 10.17605/OSF.IO/RGZE3 source

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