Despite the rarity, bone tumors are among the most types of cancer that influence patients’ quality of life by causing pain, fatigue, and reduction in physical activity level, as well as having substantial psychological and social impact. The purpose of this study is to assess the quality of life of patients who have been diagnosed with bone tumor. This descriptive study used WHO quality of life questionnaire, EORTC QLQ-C30, EORTC QLQ-BM22, to collect data from 120 patients in (specialized nuclear medicine and oncology hospital), from December 1, 2021 to March 1, 2022. Descriptive and inferential statistics utilized to analyze data by (SPSS) program version 27, with Chi-square test and P<0.05 significant level. (87.5%) of patients were diagnosed with metastatic bone tumor, while (12.5%) diagnosed with primary bone tumor, the highest percentage of patients was women (66.7%). The study found that the bone tumor had negative impact on patient quality of life in term of physical activity, fatigue, inability to work, worry and negative feelings, and sleep problems. Metastatic bone tumor is significantly more common than primary bone tumor. Bone tumors have significant impact on patients’ quality of life in physical, independency, and psychological domains. There is a significant correlation between patient’ financial difficulties and his or her psychological condition.