This study was conducted as a descriptive study to determine the quality of life (QoL), mental states and affecting factors in Multiple Sclerosis (MS) patients receiving treatment in an Ibn Sina Teaching hospital, City of Mosul, Iraq. The sample of the study consisted of 100 patients with MS diagnosed in Ibn-Sina teaching Hospital, City of Mosul, Iraq; who were being treated in the Neurology Diseases Clinic and were followed up in the outpatient clinic and accepted to participate in the study. “Short Form SF-36” and General Health Questionnaire -12 were used as data collection tools. In the analysis of the data, descriptive statistics, independent groups t test, Mann Whitney U test were used. 64.6% of the patients participating in the study were women, 64.4% were married, 44.4% were not working. 11.1% of the patients had a family history of MS and 13.3% were using assistive devices. It was determined that 26.8% of the patients had a high risk of experiencing mental problems. The mean score of the General Health Questionnaire-12 scale of the patients using assistive devices was significantly higher (p<0.05). According to the results of the study, it was determined that the QoL of MS patients was low and the mental status of nearly half of the patients was not good.