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19 Apr 2024 (Vol 47 , Iss 04 )

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30 Apr 2024 (Vol 47 , Iss 04 )

Journal ID : TMJ-02-10-2021-10688
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Title : Prediction of B lymphocytes epitopes which can lead to the development of a synthetic vaccine for the coronavirus COVID-19 (SARS-CoV-2)

Abstract :

The outbreak of the novel coronavirus in Wuhan in the Hubei province of China (SARS CoV-2) that began in December 2019 presents a significant and urgent threat to global health. As of september 2021, this epidemic had spread to 170 countries with 219000000 confirmed cases, including 4550000 deaths. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Until nowadays, vaccination is is the only remedy to protect humans from this SARS CoV-2. In this study, we used an immuno-informatic approach to find B cell epitopes that will help build a universal vaccine. To this end, we first built a consensus sequence for the structural protein Spike (S protein). Parallel bioinformatic predictions identified a priori potential B cell epitopes for SARS-CoV-2. These predictions can facilitate effective vaccine design against this virus of high priority. In this study, The 475-487 epitope is the best it can be for continuous and discontinuous by the 5 predictive methods. Additional studies are necessary to confirm the addability of this epitope for possible use in the development of a SARS CoV-2 vaccine.

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