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25 Apr 2024 (Vol 47 , Iss 04 )

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30 Apr 2024 (Vol 47 , Iss 04 )

Journal ID : TMJ-04-01-2023-11483
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Title : Potential of Nigella Sativa on Anti or Pro-apoptotic Pathway After Brain Injury Via Brain-derived Neurotrophic factor on Rattus Norvegicus Wistar

Abstract :

Black cumin may affect BDNF production to achieve the anti-apoptotic pathway due to its molecular structure. Black cumin as a neuroprotectant in brain injury (cerebral contusion) or trauma models is unusual. This study examined how black cumin affected BDNF neuron cells in Rattus norvegicus wistar head damage. The experimental animals were divided into the following four treatment groups: Group JH1: after the brain contusion was conducted, they were fed with black cumin extract 200 mg/kg bw every day for 7 days. After a brain contusion was conducted on Group JH2, they were given black cumin extract 300 mg/kgbw each day for seven days. Group JH3: After the brain contusion was conducted, they were fed with black cumin extract 400 mg/kg bw every day for 7 days. Group K: after the brain contusion was given Nacl 0.9% 3 ml per day for 7 days. JH3 group (400mg/kgbw) with an average BDNF (65.46 ng/ml), JH1 group (200mg/kgbb) (14.93 ng/ml) when compared to control (18.96 ng/ml), and JH2 group (300mg) with BDNF levels (22.04 ng/ml) that were nearly the same as the control. 400 mg of black cumin boosted BDNF levels dramatically (P=0.000). The higher the quantity of black cumin administered, the lower the amount of apoptosis seen (P=0.076). And as BDNF levels increased, neuronal apoptosis decreased (P = 0.004). In experimental rats who had suffered head trauma, the injection of black cumin extract led to an increase in BDNF levels. In experimental rats who had suffered head trauma, the administration of black cumin extract led to a reduction in apoptosis.

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