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Journal ID : TMJ-07-12-2022-11465
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Title : PLATELET/LYMPHOCYTE RATIO, NEUTROPHIL/LYMPHOCYTE RATIO, AND D-DIMER LEVELS AS PREDICTORS OF OVARIAN MALIGNANCY

Abstract :

Ovarian malignancy is the second most common gynecological cancer and has a significant fatality rate. Several indicators are elevated in malignancy, including the ratio of platelets to lymphocytes, neutrophils to lymphocytes, and D-dimer levels. The prognosis for ovarian cancer is improved by the use of these three diagnostic measures. The purpose of this study is to reveal the function of preoperative D-dimer levels, platelet/lymphocyte ratio, and neutrophil/lymphocyte ratio as markers of ovarian cancer. A cross-sectional research design was used for this diagnostic test. The study was carried out at Dr. Kariadi Central General Hospital, Semarang from January to December 2017. For categorical data, the Chi-Square Test, Fisher Exact, and Kolmogorov-Smirnov tests were used in statistical analysis. By using the Kolmogorov-Smirnov test, the normality test was conducted. Data analysis using one variable and two variables was done. Bivariate analysis using the Unpaired T-Test (assuming the data distribution is normal) or the Non-Parametric Test Mann-Whitney (if the data distribution is not normal). The ROC curve was used to assess the cut-off values for the platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and D-dimer levels. A total of 123 women met the requirements for the research. The mean platelet/lymphocyte ratio was significantly higher in the malignant ovarian neoplasm group than in the benign ovarian neoplasm group. A total of 123 women met the requirements for the research. The mean platelet/lymphocyte ratio was significantly higher in the malignant ovarian neoplasm group than in the benign ovarian neoplasm group (272,74±239,32 vs 203,81±193,3, p<0,05). The mean neutrophil/lymphocyte ratio was significantly higher in the malignant ovarian neoplasm group compared to the benign ovarian neoplasm group (4,43±7,39 vs 4,21±4,26, p<0,05). In the malignant ovarian neoplasm group, the mean D-Dimer level was significantly higher than in the benign ovarian neoplasm group (5201,45±6203,34 vs 1081,80 ±1360,03, p<0,05). This ROC curve was used to calculate the cut-off point for the platelet/lymphocyte ratio of 179.52, the neutrophil/lymphocyte Ratio of 2.62, and the D-Dimer level of 1240. The risk ratio (RP) of ovarian cancer is 1,558 and 3,083 times greater for people with a platelet/lymphocyte ratio and D-dimer levels exceeding the cut-off point, respectively. There is an association between platelet/lymphocyte ratio and D-Dimer levels with the incidence of ovarian tumor malignancy. Meanwhile, there was no association between the neutrophil/lymphocyte ratio and the incidence of ovarian tumor malignancy. The ratio of platelets to lymphocytes and D-Dimer levels can be used as early indicators of ovarian cancer, without disrupting the previous clinical examination.

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