COVID-19 virus has become a global infectious disease. Cytokine storm syndrome is involved in the severity of the disease. It is therefore crucial to investigate biomarkers are involved in the severity of the virus. The aim of this study was to investigate some cytokine storm syndrome markers are elevated during COVID-19 invades. Blood samples were taken from forty COVID-19 patients (regardless of gender). COVID-19 patients were confirmed by real time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELIZA) IgM and IgG antibodies. Severe, non-severe COVID-19 patients were compared to each other aged (48-61 years). Cytokine storm syndrome parameters including Interleukin-6 (IL-6), C-reactive protein (CRP), D-dimer, ferritin, procalcitonin and lactate dehydrogenase (LDH) was investigated. Whole blood was taken to perform D-dimer, ferritin and Serum was made to perform inflammation markers including CRP, procalcitonin, IL-6 and LDH. IL-6, C-reactive protein (CRP), D-dimer, ferritin, procalcitonin and LDH were significantly higher in severe patients compared to non-severe COVID-19 patients. It can be concluded that IL-6, C-reactive protein (CRP), D-dimer, ferritin, procalcitonin and LDH as markers of cytokine storm syndrome are related to the severity of CVOID-19 patients.