Title : Investigation on usefulness of serum matrix metaprotease-3 levels as a biomarker of severity and screening tool in psoriatic arthritis

A simple and highly efficient one-pot three-component synthesis of a series of pyrido [2,3-d] pyrimidines from the condensation of barbituric acid, malononitrile and aromatic aldehydes using catalytic amount of a new Ni(II) complex based on 5-nitro-N1-((pyridin-2-yl) methylene) benzene-1,2-diamine (NiL) is reported. This new heterogeneous catalyst has the advantages of being environmentally friendly, simple work-up and high yields character.