To determine the level of circulating pro-inflammatory peptides in prepubertal children and its relationship with abdominal obesity, through waist circumference measurement, and diagnose cardio metabolic risk factors. Between November 2020 and June 2021, a sample of 90 healthy Iraqi children (45 Pubertal and 45 Pubertal children) aged 6-16 years participated in this case-control study. Illness, onset of puberty, any drug intake at the time of investigation, or chronic inflammatory disease. This information was obtained through interviews and a comprehensive physical examination of the participants. A significantly higher blood sugar, total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in prepubretal children when compared with pubretal children. Serum levels of interleukin 6 are also elevated and there are significant differences between children group, the tumor necrosis factor alpha value increased significantly in the cases (p = 0.01). conclusion: in adolescence, inflammatory markers are related to risk factors for cardiovascular disease. body size, nutritional assessment and physical activity have been presented as non-pharmacological measures to control inflammation markers, resulting in effects on controlling obesity, blood lipids, insulin resistance, hypertension and diabetes.