Abstract :
The concerns of Covid-19 vaccine safety and the side effects are till now unknown. We report a case of systemic lupus erythematosus (SLE) induced with Astrazeneca Covid-19 vaccine. In fact, the patient with no history of medical allergies presented with prominent nodular skin lesions over the face, the trunk, the arms and limbs, associated with symmetric arthritis of both wrists, hands and knees. Antinuclear antibodies were positive (1:320) and skin biopsy revealed basal layer degeneration, interface dermatitis with a mononuclear cell infiltrate at the dermal-epidermal junction and perivascular lymphocitic infiltrate. Of note, the patient received the first dose of Covid-19 vaccine (Astrazeneca) 5 days before the onset of cutaneous findings. She was then, diagnosed with systemic lupus erythematosus and treated with corticosteroids and Hydroxychloroquine and cutaneous lesions and arthralgias disappeared.
