Demonstration of the disease hallmarks of COVID infection 2019 (Coronavirus disease-19) caused by respiratory SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) in tissue biopsies and some autopsy examinations confined to the pulmonary system and selective target tissues. Entire corpse dissection investigation was limited. To characterize the extent of pathological changes resulted by COVID-19 infection, examinations carried out on twelve (12) cases with SARS-CoV-2 (Nine '9' were healthy & Three '3' unhealthy) some passed out in home and others in hospitals at Baghdad. Specimens from the pulmonary, cardiac, hepatic, renal systems with splenic samples only have been inspected both grossly and microscopically. SARS-CoV-2 resulted in multiple organs illness, lungs with circulatory association was predominant. Extra-pulmonary signs include liver, kidney and spleen contribution, and microvascular injury was obvious. These results were documented both in patients with or without previous clinical history of diseases. SARS-CoV-2 resulted in multiple organs illness & critical disease in many systems regardless of previous medical background.