Abstract :
Cleome Ciliata is a famous medicinal plant from the Cleomaceae family and is widely used in traditional medicine to treat various ailments. However, there are no toxicological data on safety after repeated exposure and long-term use; therefore, the present study was designed to evaluate the 90-day chronic toxicity of ethanol (80%) Cleome ciliata extract in adult Wistar. A chronic toxicity experiment was conducted by oral administration of graded doses (250 mg/kg, 500mg/kg and 1000 mg/kg) of test extract daily for 90 days. Signs of toxicity and body weight were evaluated. The toxic effects were also assessed using haematological and electrolyte data. All data collected were expressed as mean ± standard deviation. ANOVA followed by post hoc Turkey’s test was used for data interpretation and p<0.05 was considered significant. There were no treatment-related differences in haematological and electrolyte indices. Moreover, no gross abnormalities or histological alterations were observed. No deaths or evident of toxic signs were found during the experimental period. There were no significant differences in body weight between the control and the treated groups. The ethanol extract of cleome ciliata leaves was nontoxic in chronic intake at the dosages tested. Thus, this study demonstrated potential safe clinical applications and warrant further clinical studies.
