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30 Jun 2024 (Vol 47 , Iss 06 )

Journal ID : TMJ-13-03-2022-11192
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Title : Gene- polymorphisms in Tell Like Receptors (TLR-2 and TLR-9) with Cytomegalovirus infection in aborted women

Abstract :

Human cytomegalovirus (HCMV) is the most frequent cause of congenital infection in humans. Infection with HCMV is very common worldwide with seropositivity rates ranging from 40% in developed countries up to 99% in developing countries. Toll-like receptors (TLRs) play a crucial role as a first line of host immune defense against (HCMV). Owing to the high percentage of CMV among aborted women with recurrent miscarriage, therefore, the gene polymorphisms of Toll- like receptor (TLR-2 and TLR-9) in CMV aborted women was examined by using a high resolution melting PCR. Seventeen cervical swabs out of 54 were positive for CMV obtained from aborted women from Baghdad maternity hospitals and seventeen cervical swabs as a control group obtained from healthy women for ages (17-40) years old. The result of gene polymorphism of TLRs (TLR-2, SNP rs-5743708 and TLR-9, SNP rs-352140) in CMV aborted women, showed that the homozygous mutant A/A appeared in 58.8% (OR= 22.8571, CI= 2.4349 to 214.5638, P=0.006). The is indicate the significant role TLR-2 A/A genotype in CMV escape from immunity of aborted women. Whilst TLR-9 SNP in CMV infected women resulted in 52.9% of patient had a heterozygous mutant C/T (OR= 39.1176, CI=2.02779 to 754.5664, P=0.015). These results indicated that TLR-2 mutant SNP had a significant impact on CMV aborted women than TLR-9 SNP. In conclusion, genetic polymorphisms of TLR-2 had a significant role in CMV infected women, rather than TLR-9 SNP, which many correlated with miscarriages in Iraqi women.

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