A descriptive design, which is using the evaluation approach, is conducted through the period of January 10th to November 1st, 2021, to evaluate the Routine Childhood Immunization Program Outcome at Primary Health Care Centers in Salah Al-Dean Governorate. The study is using a multistage "non -probability" convenient sample of (thirty-two) primary health care centers (sixteen main and sixteen sub main) distributed in Salah Al-Dean health directorate. An instrument is developed of the Pan American Health Organization and World Health Organization for the purpose of the present study. The study instrument is consisted of the evaluation of Routine Childhood Immunization Program Outcome at Primary Health Care Centers. Content validity and internal consistency reliability are ascertained for the study instrument through a pilot study. The data are gathered through the utilization of the study instrument and the structured interview technique as data gathering method. The data are analyzed through the using of descriptive statistical data analysis approach which includes (frequencies, percentage, mean, total scores, and ranges). The study results present that all of the main primary health care centers and majority of the sub primary health care centers have good level of overall evaluation of the Routine Childhood Immunization Program outcome (100%) (87.5%) respectively. The study concludes that the Routine Childhood Immunization Program outcome is adequately employed at all of the Main Primary Health Care Centers and majority of the sub primary health care centers have presented continuous, cost-effective and adequate immunization services. Likewise, the present study recommends that the Routine Childhood Immunization Program at the Main and Sub primary health care centers should be occupied with all the necessities of the outcome for the benefits of consumers.