Abstract :
To investigate the effect of moist exposed burn ointment (MEBO) in the healing of cutaneous wounds of rabbits. The study was done at the Department of Oral and Maxillofacial Surgery, Dentistry College, Mosul University, included 25 domestic male rabbits1- 1.5 kg body weight and 1-2 years of age. The animals were divided into 2 groups according to times of taking biopsies; Each group consisted of 5 animals. On each animal, three full-thickness skin wounds 3cm*3cm in diameter were created. One wound on each animal served as a control, the second wound on each animal was covered by MEBO every day. The wounds were investigated histopathologically for wound healing after 3, 7 and 14 days. The wounds which served as control were covered by ultra-sound gel. The other wound was covered by MEBO. Then all back dorsal wounds were dressed by gausses. The day when wounds were made was designated as the first day, and the process of wound healing was observed from 3 days after wounding. We observed rabbit skin of A1 (3 days) group shows the site of wound with sloughing the mucosal epithelium, inflammatory crust; composed of inflammatory exudate; and infiltration of inflammatory cells (score 3). so, the rabbit skin for group A2 (3 days) group shows the site of wound with sloughing the mucosal epithelium; inflammatory crust composed of inflammatory exudate; and infiltration of inflammatory cells (score 3); As a result, the rabbit skin of group A2 (3 days) shows an inflammatory crust; constituted of inflammatory exudate; hyperkeratosis; and cellular debris with inflammatory cells (score 3); with blood vessel congestion; the skin of a rabbit for three groups appearance wound site with discontinuous re-epithelialization (Score 1), formation of granulation tissue (Score 1&2); constituted of fibrous tissue; angiogenesis; and inflammatory cells (score 1) are shown in the A1 and 2 groups. as well as the site of skin wound for group A1 appearance discontinuous re-epithelialization (Score2& 3); formation of granulation tissue (Score 2); composed of fibrous tissue growing perpendicular to the wound; angiogenesis; and mild infiltration of inflammatory cells (score 1&2), whilst the site of wound with re-epithelialization (Score 3), as well as for group A2 rabbit skin appearance site of the wound with tight flap and discontinuous re-epithelialization (Score 3), formation of granulation tissue (Score 2,3), composed of fibrous tissue growing perpendicular to the wound, angiogenesis and mild infiltration of inflammatory cells (score 1). MEBO accelerated wound healing and boosted neovascularization in cutaneous excisional wounds by promoting the development of granulation tissue. MEBO enhances cutaneous excisional wound healing and is recommended for the treatment of cutaneous wounds that are slow to heal.
