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21 May 2022 (Vol 45 , Iss 04 )

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31 May 2022 (Vol 45 , Iss 03 )

Journal ID : TMJ-21-12-2021-10920
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Title : Evaluation and Identification of The Genotypic and Allelic Frequency of HMGB1 and RAGE Genes Polymorphisms in Patients with Breast Cancer

Abstract :

Breast cancer (BC) is the most frequent cancer in women all around the world. It is the most frequently diagnosed tumor and has the 6th highest malignancy-related mortality rate. A strong familial clustering of breast cancer suggests that a genetic component underpins its carcinogenesis HMGB1 overexpression has been indicated in breast cancer patients. The receptor for advanced glycation end products (RAGE) is highly expressed in various cancers and is correlated with poorer outcome in breast and other cancers. The present study aimed at identification the genotypic and allelic frequency of HMGB1 (rs4145277), (rs1412125) and RAGE (rs184003), (rs1800624) genes polymorphisms in patients compared with normal population by using ARMS PCR and the association of its susceptibility to Breast cancer in a group of 50 Iraqi women patients, in whom the Breast cancer has been already diagnosed and compared to a group of apparently healthy (control group N= 50) individuals. The ARMS PCR was used for the HMGB1 and RAGE genes polymorphisms in all members of the study. On the context of genotyping of HMGB-1 rs4145277 poly gene polymorphism, shown the heterozygous genotype CT and homozygous genotype CC were more frequent in patients group in comparison with control group, and allele C was more frequent in patients group in comparison with control group. HMGB-1 rs1412125 poly gene polymorphism, shown the homozygous genotype CC was more frequent in patients group in comparison with control group, allele C was more frequent in patients group in comparison with control group of rs1412125 poly allele polymorphism. RAGE rs184003 poly gene polymorphism, shown the heterozygous genotype AC and homozygous genotype CC were more frequent in patients group in comparison with control group, and allele C was more frequent in patients group in comparison with control group. RAGE rs18400624 poly gene polymorphism, shown the heterozygous genotype TA and homozygous genotype AA were more frequent in patients group in comparison with control group, allele A was more frequent in patients group in comparison with control group of rs18400624 poly allele polymorphism.

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