Abstract :
The increased demand for day case laparoscopic procedures mandates a general anesthetic technique with rapid recovery and minimal side effects. Our study aimed at comparing sevoflurane (S) versus desflurane (D) using a more sensitive and specific biomarker of renal functions (Cystatin) in patients undergoing elective laparoscopic cholecystectomy. The study was a prospective randomized study that included 70 patients (D, n = 35 and S, n = 35) undergoing laparoscopic cholecystectomy surgeries. Cystatin-C and standard kidney function tests (BUN and creatinine) were assayed. The cystatin showed early elevations at 1 hour postoperatively in both groups, with no adverse clinical renal effects. Sevoflurane and desflurane both cause comparable elevations of cystatin levels during limited duration laparoscopic procedures. This may indicate an affection of renal integrity, as cystatin is a sensitive and specific biomarker of renal integrity, but there were no adverse clinical manifestations in those patients undergoing laparoscopic cholecystectomy.
