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Journal ID : TMJ-17-07-2022-11339
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Title : Evaluating the clinical significance of insulin resistance, oxidant/ antioxidant status, some adipokines, and glycoproteins as monitoring indicators in Type 2 diabetic foot syndrome

Abstract :

Diabetic foot syndrome (DFS) is a long-term consequence of diabetes caused by both micro and macrovascular issues. Due to the paucity of information and researches on DFS in Basrah, Iraq, in this study we examined and compared the role of insulin resistance (IR), oxidant/antioxidant status, some adipokines and glycoproteins in Type 2 diabetic patients with DFS. This was a case-control study involving 89 subjects, consisting of 45 DFS subjects and 44 healthy subjects. Their fasting Insulin, chemerin, Zonulin, ceruloplasmin, α2-macroglobulin, Malondialdehyde (MDA) and Total antioxidant capacity (TAC) were determined by ELISA methods. Demographics, glucose was assayed on UV-Vis Spectrophotometer, HbA1c measurement was determined using the Bio-Rad D-10® HPLC analyzer, and homeostasis model assessment for determined of insulin resistance (IR). When compared to controls, glucose, Insulin, HOMA-IR, HbA1c, Chemerin, Ceruplasmine, Zonulin, α-2Macroglobulin and Malondialdehyde levels were significantly elevated (p<0.01), while total antioxidant capacity was lowered (p<0.01). These measures could potentially be employed as prognostic biomarkers in both men and women with DFS, according to the area under the curve (AUC). The associations of insulin resistance (IR) with examined adipokines and glycoproteins were not significantly different, which may shed new light on the role of IR as an etiological cause of DFS and suggest that it could be a better monitoring index in women and men with DFS.

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