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20 May 2024 (Vol 47 , Iss 05 )

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31 May 2024 (Vol 47 , Iss 05 )

Journal ID : TMJ-12-06-2023-11541
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Title : Emerging issues, genome diversity and risk factors in infections due to Klebsiella pneumoniae carbapenemase -producing K. pneumoniae (KPC-KP)

Abstract :

Klebsiella pneumoniae is the third most frequently reported healthcare-associated pathogen and causes a variety of severe systemic infections, including bloodstream infections (BSIs), hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and complicated urinary tract infections (cUTIs). To investigate antimicrobial resistance, genome diversity, risk factors and associated challenges in the management and treatment of patients with infections because MDR Klebsiella pneumonaie. Study Population and strains: K. pneumonaie isolated from various clinical samples received in the Department of Microbiology, of tertiary care hospital Pune Maharashtra India. A total of 100 [22%] K. pneumonaie were isolated from 458 clinical samples. Male patients were more predominant than female patients distributed in the population. Patients of all ages were considered in this study, but the frequency was for 40-65 years. PCR experiments were carried to sequence these six antibiotic resistances encoding genes. Of the 35 samples, 30 (86%) were positive for blaCTX-M -15 gene, 24 (68%) were positive for blaTEM and blaSHV gene; none of them were positive for KPC gene, 20 (57%) were positive for blaNDM gene and 6 (17%) were positive for blaDHA gene. Genomic DNA was stored for next-generation whole genome sequencing. K. pneumoniae were found to be multidrug-resistant. Therefore, there are very few therapeutic options for treating MDR K. pneumoniae, portraying a gloomy picture for hospital infection management suggesting that a proper surveillance system should be implemented to prevent an impending healthcare management disaster.

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