Stroke is the highly common neurological disorder that can be fatal or severely disabling. and a serious public health problem, it is the third major public health problem and the fourth leading cause of disease burden in the global. The aim of this study was to evaluate serum electrolytes and renal function parameters after acute stroke. During the study period from December 2020 to September 2021.One hundred patients (males and females) were included from two teaching hospitals (Ibn-Sena and Al-Salam) in Mosul City in Iraq. The demographic and clinical data, particularly the clinical presentation at the time of admission were recorded on a standardized data sheet. Clinical examination and a CT scan of the brain were performed to confirm the diagnosis. On the day of admission, a blood sample was obtained for electrolytes analyzed in addition to serum BUN and Cr. The NIHSS was used to determine the severity of stroke. The patients' functional outcomes were followed for up to three months using a modified Rankin Scale, as follows: good functional (0 - 3), poor functional outcomes (4 - 6). The study found that among 100 patients; (55%) were males and (45%) were females. The mean age was 59.71 ± 14.018. There were (84%) cases of ischemic stroke and (16%) cases of hemorrhage. Most respondents having electrolytes imbalances and potassium disturbances were the most encountered (56%) followed by sodium disturbances (52%). This electrolytes abnormalities were commonly among acute stroke cases who died within three months of follow up, also hyperuricemia and hyper creatinine contributed to high rate of mortality in stroke patients. This study concluded that electrolyte disturbances are quite common problem in acute stroke along with serum BUN and Cr, which are useful adjuvant biochemical markers that can aid in prompt medical intervention, avoid any complications and resultant improved outcomes in stroke patients.