21 May 2022
31 May 2022
This study investigated the effect of V. amygdalina on the hematological parameters and kidney function in Wistar rats exposed to stress. 25 Wistar rats were randomly assigned to five groups. NCG (control) was given water only, T1S0 was given V. amygdalina extract but not stressed, T2S24, T3S36, and T4S48 were given same concentration of V. amygdalina extract (100mg/kgBW) and stressed for 24hours, 36 hours and 48hours respectively. Hematological test was carried out by Mindray Haematology Analyzer BC-2800 and creatinine/urea tests were performed using Randox method. The result reveals increased WBC count in all treatment groups, which was significant only (P<0.05) in treatment group T4S48=21.28x103/mm3. The Hb concentration significantly increased in T1S0=14.86 x103/mm3 and T2S24=14.88 x103/mm3 respectively. There was significant (P<0.05) increase in serum creatinine (T1F0=0.196*, T2F24=0.191* and T3F36=0.175*) and urea concentration (T1S0=52.1* and T2S24=48.6*) when compared with their control. The result further revealed that increased duration of fasting stress progressively decreased serum creatinine (T2F24=0.191, T3F36=0.175 and T4F48=0.164) and urea (T2S24=48.6, T3F36=36.4 and T4S48= 26.0) concentration. These findings indicates that the boiled bitter leaf extract is able to improve hematological parameters but may compromise kidney function and that increased duration of fasting may have some reno-protective effects.