The main therapeutic goals in ulcerative colitis (UC) are to maintain excellent quality of life by managing stress on the patient's Psychological state and preventing attacks. Because stress can trigger UC flare-ups. The effects of stress on the immune system and the inflammatory system are complex and depend on both the duration and severity of the stress. Both chronic stress and acute stress are associated with changes in systemic immune and inflammatory function that may be relevant in the pathogenesis of ulcerative colitis. Find out the effectiveness of stress management on psychological status of patients with ulcerative colitis. Find out the relationship between the effectiveness of stress management and patient age, gender, marital status, level of education, occupation, monthly income, and residency. A quasi -experimental design study was performed on patient who attended to Gastroenterology and Hepatology Teaching Hospital, from March 2021 to September 2021. The non-probability sampling including 50 patients for case study and 30 patients for control group. The questionnaire consists of 4 parts, part one the socio-demographic consist of 8 items. Part two consist of 20 items related to patient stress and fatigue. Part three dealing the Stress reduction methods, which include 8 items. Part 4 consist of 7 items related to patient uses of stress management. The results of present study revealed that 64.8% of case group show moderate level of stress and fatigues among at pretest time while during post-test time was decrease to 55.2% at posttest, their methods of stress reduction at pretest was 72.8% for agreement for these methods ant it improved at posttest was 96.6%. In addition, patient used stress management at pretest was 64% and their used improved after applying the instruction program to 98.3% at posttest. The study concluded that the stress management was effective on case group.