To assess the Effect of Radiation Therapy on Skin in Breast Cancer for Woman in AL-Amal Hospital. A descriptive design was carried out on Assessment the effect of radiation therapy on women skin in AL-Amal Hospital. In Baghdad city. the study sample consist of 158 breast cancer women who receive the radiation therapy. The questionnaire format is used to collect the data which consist of three parts, first about demographic characteristic, second general health information and third effect of radiation therapy on skin. Descriptive and inferential statistical analyses were used to analyse the data by using SPSS package. The highest percentage (69%) of the study sample was housewives and single (82.9%). not smoking (74.7%) and within reproductive age (83.3%). The (64.6%) of them have breast and axillary lymph node.and using the radiotherapy dose (4050Rad/15f) the (89%). The half of women have a change in skin color to white (50%).the study show that the effect of radiation at stage three occur in week two of therapy (61%: p. Value :0.013) and the causing itching of the skin (74%; p. Value: 0.022), fungal skin infections (82%: p.value:0.01). while there is no signigicant relationship between site of treatment and effect of radiation therapy on the skin in all items. The study recommended developing plans of training courses for the mother and health care providers about effects of radiation therapy on the skin to reduce the symptoms that occur related to radiotherapy treatment.