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27 Jun 2024 (Vol 47 , Iss 06 )

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30 Jun 2024 (Vol 47 , Iss 06 )

Journal ID : TMJ-28-05-2024-11603
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Title : Effect of intravenous ondansetron on hemodynamic changes induced by spinal anesthesia in patients undergoing ureteroscopic surgery

Abstract :

Hypotension and bradycardia are the common side effects seen after spinal anesthesia. Multiple strategies are tested to prevent the post-spinal anesthesia‑induced hypotension and bradycardia Recently, Ondansetron, a 5‑HT3 antagonist commonly used as an antiemetic, has been safely used to blunt the Bezold–Jarisch reflex, resulting in less bradycardia and hypotension in humans undergoing spinal anesthesia. Is to evaluate effectivness of intravenous ondansetron in the prevention of spinal anesthesia‑induced hypotension and bradycardia in patients undergoing ureteroscopy. This was a randomized controlled blinded study done over a period of 4 months from February 2021 to June 2021 in imam al-hussain medical city, Karbala. 60 patients aged 18–65 years, with ASA status I and II, scheduled for ureteroscopy under spinal anesthesia were divided into two equal groups in a randomized-controlled fashion. Before induction of spinal anesthesia, group I (n=30) received intravenous ondansetron 8 mg and group II (n=30) received normal saline. Hemodynamic variables, such as systolic blood pressure, diastolic blood pressure, heart rate (beat/min), mean arterial blood pressure (mmHg), nausea, vomiting, shivering, and vasopressor requirements (mg), were recorded for each patients. The decreases in systolic, diastolic and mean arterial pressure as well as heart rate were significantly lower in group I than in group II. Patients in group I had significantly less requirement for vasopressor than in group II, and had significantly lower incidences of nausea and vomiting, But in shivering, there was no statistically significant difference between the two groups. In patients undergoing ureteroscopy under spinal anesthesia, intravenous 8 mg ondansetron significantly decreased the hypotension, bradycardia, and vasopressor requirements, ondansetron showed no significant effect on shivering in our study.

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