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20 Jun 2024 (Vol 47 , Iss 06 )

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30 Jun 2024 (Vol 47 , Iss 06 )

Journal ID : TMJ-31-01-2021-10509
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Title : Dialysis Disequilibrium Syndrome: Pathophysiology and Management

Abstract :

Dialysis disequilibrium syndrome (DDS) is defined as a clinical syndrome of neurologic abnormalities seen in patients undergoing hemodialysis. There are several theories that support the mechanism for DDS, such as Urea Transporter and Aquaporins in the brain, reversed urea effect, idiogenic osmole, metabolic and cerebral acidosis mechanism. Dialysis disequilibrium syndrome is a clinical condition diagnosed in patients at risk undergoing hemodialysis. There is no laboratory examination for DSS and is still a diagnosis of exclusion. The main target in the management of DDS is to reduce brain edema and prevent complications.7 If DDS is suspected in a patient, strong consideration should be given to discontinuing dialysis therapy. Patients should always be closely monitored and if any deterioration occurs, stop the hemodialysis immediately. Severe symptoms should improve within 24 hours after dialysis is stopped.

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